| Abstract | Nineteen electroencephalographic (EEG) sleep measures describing four physiologic aspects of sleep
behavior (i.e. sleep continuity, EEG spectra, body and eye movements, and autonomic measures) were
derived from visual and computer analyses of 71 24-channel, 3-hour EEG sleep recordings on 52 healthy
preterm neonates from 28-36.5 weeks postconceptional age (PCA). Forty-eight subjects were
neurodevelopmentally normal up to 2 years of age. Four electrographic states that comprise trace discontinu
of the preterm neonate were defined in terms of increasing seconds of EEG quiescence per minute. A
regression analysis was performed after transformations of nonlinear data sets representing the 19 EEG
sleep measures, with the four sleep states as outcome variables. Postconceptional age was also included in
these analyses as the 20th explanatory variable. Four measures best defined the EEG sleep states, explaining
75% of the variance: decreasing rapid eye movements per minute, decreasing numbers of spontaneous
arousals per minute, increasing spectral theta energies, and decreasing facial movements per minute. Other
cerebral and noncerebral measures, including total spectral EEG energies, spectral EEG energies in three
bandwidths (i.e. delta, alpha, beta), cardiac and respiratory measures, and body movements, did not
contribute as significantly to the prediction. Inclusion of PCA into the regression equation with the four EEG
measures, selected by the analysis procedure, indicated that its contribution to state prediction was also
small; the effect of PCA on state was found to be explained by the four EEG sleep measures. |